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Targeting the mitochondrial-associated endoplasmic reticulum membrane to regulate calcium homeostasis: ShenfuYixin Granules counteract myocardial ischemia-reperfusion injury through the sGC/PKG pathway
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DOI：10.1016/j.phymed.2026.158264.png)
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Abstract
En 中文
• SFYX prevents myocardial ischemia-reperfusion injury by targeting mitochondrial-associated endoplasmic reticulum membranes. • The sGC/PKG signaling pathwayis the basis for SFYX to regulate mitochondrial calcium homeostasis. • SFYX reduces oxidative stress and apoptosis in cardiomyocytes through MAMs stabilization. • Network pharmacology and experimental validation confirm SFYX's preventive mechanism against MIRI. • SFYX provides a new direction for clinical prevention of MIRI and its late complications, such as heart failure and malignant arrhythmia.
Keywords:
Myocardial ischemia reperfusion injury
Mitochondria-associated endoplasmic reticulum membranes
Mitochondrial calcium overload
Oxidative stress
Traditional chinese medicine
MIRI
Myocardial ischemia-reperfusion injury
SFYX
Shenfuyixin granules
ROS
Reactive oxygen species
MAMs
Mitochondria-associated endoplasmic reticulum membranes
AMI
Acute myocardial infarction
mPTP
Mitochondrial permeability transition pore
TCM
Traditional Chinese medicine
H/R
Hypoxia-reoxygenation
Mitosox Red
Mitochondrial superoxide assay
Rhod-2 AM
Rhod2 co-immunofluorescence probe with mitochondrial tracer
DEGs
Differentially expressed genes
ER
Endoplasmic reticulum
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