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Targeting the Polycomb repressive complexes in hepatocellular carcinoma: A comprehensive and updated analysis of mechanistic insights and clinical application
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DOI：10.1016/j.bbcan.2026.189589.png)
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Abstract
En 中文
• Polycomb Repressive Complexes (PRC1 and PRC2) are essential drivers of transcriptional repression and play critical roles in HCC progression. • PRC1 or PRC2 dysregulation promotes key hallmarks of HCC, directly linking epigenetic alterations to tumorigenic and malignant phenotypes. • PRC1 and PRC2 serve as key therapeutic targets, providing a rationale for epigenetic therapies against HCC and other cancers.
Keywords:
Polycomb Repressive Complexes
Hepatocellular Carcinoma
Epigenetic Regulation
Transcriptional Repression
Therapeutic Targets
Journal
B
IF:
0
Papers:
105
Citations:
0
Organization
Cited Papers