Targeting tumor cell-intrinsic POU4F1 enhances antitumor immunity and sensitizes tumors to immunotherapy in basal-like breast cancer by modulating macrophage recruitment and polarization

2026-07-23

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Jiahui Zhang

Nanyan Miao

Yunzhi Guo

Yixuan Liu

Yan Zhou *

Xin Zeng *

Di Huang *

DOI：10.1016/j.canlet.2026.218763

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• Tumor cell-intrinsic POU4F1 contributes to the establishment of an immunosuppressive microenvironment in basal-like breast cancer. • POU4F1 promotes monocyte recruitment and immunosuppressive phenotype polarization of macrophages through NIK-P52/RelB-CCL2 axis. • Increased macrophage infiltration and immunosuppressive polarization inhibits the proliferation and effector functions of CD8+ T cells and NK cells. • Targeting POU4F1 inhibits tumor growth, restores antitumor immune response and potentiates immunotherapy.

Targeting tumor cell-intrinsic POU4F1 enhances antitumor immunity and sensitizes tumors to immunotherapy in basal-like breast cancer by modulating macrophage recruitment and polarization

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