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Targeting vulnerabilities in IDH mutant tumours: The model matters
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DOI：10.1016/j.neo.2026.101338.png)
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Abstract
En 中文
• The model system influences therapeutic vulnerabilities in IDHMUT cell lines. • Therapeutic vulnerabilities in non-endogenous IDHMUT models may be model artifacts. • IDHMUT overexpression and high D-2-HG levels induce treatment sensitivities. • Non-endogenous IDHMUT models can generate false positive therapeutic leads. • Use of endogenous IDHMUT models is recommended for clinical translation.
Keywords:
IDH1/IDH2 mutations
D-2-hydroxyglutarate
synthetic lethality
in vitro models
CRISPR-Cas9
chondrosarcoma
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