logo
CanyamAI summaries for academic research
language
MobileMobile
  • Phone FeatureWeChat Mini Program
EnglishEnglish
noticeNotice
BlogBlog
delete
arrow
Return

Telomere structure and function in trypanosomes: a proposal

delete2006-12-11
delete60
PRE
AI
O
Oliver Dreesen
B
Bibo Li
G
George Cross *
DOI：10.1038/nrmicro1577delete
deleteOriginal
deleteOriginal request for help
deleteShare
deleteSave
Abstract

Abstract

En 中文
Telomeres are specialized DNA - protein complexes that stabilize chromosome ends, protecting them from nucleolytic degradation and illegitimate recombination. Telomeres form a heterochromatic structure that can suppress the transcription of adjacent genes. These structures might have additional roles in Trypanosoma brucei, as the major surface antigens of this parasite are expressed during its infectious stages from subtelomeric loci. We propose that the telomere protein complexes of trypanosomes and vertebrates are conserved and offer the hypothesis that growth and breakage of telomeric repeats has an important role in regulating parasite antigenic variation in trypanosomes.
Keywords:
D-GLUCOSYL-HYDROXYMETHYLURACIL
GENE-EXPRESSION SITES
DNA-DAMAGE RESPONSE
ANTIGENIC VARIATION
AFRICAN TRYPANOSOMES
HOMOLOGOUS RECOMBINATION
HUMAN-CHROMOSOMES
LENGTH REGULATION
T-LOOPS
BRUCEI
AI Summary

AI Summary

Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

N
Nature Reviews Microbiology
IF:
103.3
Papers:
3.5K
Citations:
6.1W

Organization

No organization information available