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Tenascin‑C promotes epidural fibrosis via regulating caveolin-1-mediated TGFβRI internalization
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DOI：10.1016/j.matbio.2026.102014.png)
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Abstract
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• TNC was elevated in the epidural scar tissues either in the patients after spine surgery or in a murine laminectomy model. • Ablation of TNC via knockout significantly reduced epidural scar formation pointing at an important role of TNC in fibrosis shown to be linked to elevated fibronectin expression. • Through its Epidermal Growth Factor Like (EGFL) domains, TNC downregulates caveolin-1 involving Toll‑like receptor 4 (TLR4). • By downregulating caveolin-1, TNC relieves suppression of transforming growth factor‑β receptor I (TβRI), resulting in a profibrotic fibroblast phenotype with upregulated fibronectin expression.
Keywords:
Tenascin-C
epidural fibrosis
caveolin-1
TGFβRI
fibronectin
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