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TFOS DEWS III: Digest
DOI:10.1016/j.ajo.2025.05.040.png)
Abstract
En 中文
This digest summarizes the interdisciplinary research in dry eye disease (DED) published since the 2017 TFOS DEWS II reports. It comprises 7 topics including Sex, Gender, and Hormones; Epidemiology; Pathophysiology; Tear Film; Pain and Sensation; Iatrogenic Dry Eye; and Clinical Trial Design and explores how each of these inform diagnostic methodology, disease subtype, and management of DED.
Keywords:
ADDE
Aqueous-deficient dry eye
BALB/c
BALB/C wildtype (mice)
CI
confidence interval
CXL
Corneal cross-linking
DED
Dry eye disease
DEQ-5
5-Item Dry Eye Questionnaire
DEWS
Dry Eye Workshops
DNA
Deoxyribonucleic acid
EDE
Evaporative dry eye
FDA
Food and drug administration
(f)MRI
(Functional) magnetic resonance imaging
GVHD
Graft-versus-host disease
HLA
Human leukocyte antigen
HPMC
Hydroxypropyl methylcellulose
ICAM-1
Intercellular Adhesion Molecule 1
IL
Interleukin
IGF
Insulin-like growth factor
IVCM
In vivo confocal microscopy
LASIK
Laser-assisted in situ keratomileusis
LIPCOF
Lid-parallel conjunctival folds
LLT
Lipid layer thickness
MGD
Meibomian gland dysfunction
MGYLS
Meibomian glands yielding liquid secretion
MMP
Matrix metalloproteinase
MUC4
Mucin 4
NGF
Nerve growth factor
NIBUT
Non-invasive tear film breakup time
NF-kB
Nuclear factor kappa-light-chain-enhancer of activated B cells
NRS
Numerical rating scale
OCT
Optical coherence tomography
OR
Odds ratio
OSDI
Ocular Surface Disease Index
PRK
Photorefractive keratectomy
QoL
Quality of Life
SANDE
Symptom Assessment iN Dry Eye questionnaire
SPEED
Standard Patient Evaluation of Eye Dryness questionnaire
TBUT
Tear film breakup time
TED
Thyroid eye disease
TFOS
Tear Film & Ocular Surface Society
TRPM8
Transient Receptor Potential cation channel subfamily M member 8
VAS
Visual analogue scale
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