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TGF-beta inhibitors influence leishmania infection outcome in a susceptible host
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DOI：10.1016/j.cyto.2026.157169.png)
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Abstract
En 中文
• TGF-β receptor inhibitor, galunisertib, reduces Leishmania load in macrophages. • Galunisertib enhances nitric oxide production in macrophages. • Galunisertib enhances IFN-γ and TNF-α expression in susceptible BALB/c mice. • Galunisertib reduces splenic and hepatic parasite load in BALB/c mice.
Keywords:
TGF-β inhibitor
Leishmania
macrophages
nitric oxide
IFN-γ
TNF-α
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