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The +1 nucleosome functions in RNA Pol II transcription initiation and the transition to elongation
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DOI：10.1016/j.molcel.2026.06.042.png)
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Abstract
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• DNA translocation by TFIIH destabilizes TFIID in the presence of a +1 nucleosome • The +1 nucleosome stimulates TFIIH translocase activity and initial transcription • The +1 nucleosome facilitates TFIIH eviction during promoter escape • The +1 nucleosome both passively and actively functions in transcription initiation
Keywords:
RNA polymerase II
pre-initiation complex
+1 nucleosome
transcription
initiation
initiation-elongation transition
gene regulation
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