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The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair
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DOI：10.1016/j.devcel.2026.05.014.png)
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Abstract
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• ANXA11 rapidly localizes to and plugs holes in damaged plasma membranes • CHMP2B localizes later to sites of damage and helps externalize ANXA11 plugs • Shedding of these lesions heals the membrane and preserves cellular viability • Some FTD/ALS-associated mutations in ANXA11 and CHMP2B impair membrane repair
Keywords:
ESCRT-III
CHMP2B
ANXA11
membrane repair
annexin
FTD
ALS
pore-forming toxin
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