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The association between time-weighted cumulative life's essential 8 and aortic valve calcification
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DOI：10.3389/fcvm.2026.1763288.png)
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Abstract
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ObjectiveTo examine the association between the time-weighted cumulative Life's Essential 8 (TWC-LE8) score and aortic valve calcification (AVC).MethodsThis analysis included 15; 321 adults (mean age; 63.79 years; 76.44% men) from the Kailuan cohort who completed four health examinations between 2006 and 2012 and subsequently underwent standardized echocardiography. The TWC-LE8 score (range; 0–100) was used to classify cardiovascular health (CVH) as low (<50); moderate (50–79); or high (≥80). Multivariable logistic regression was used to estimate odds ratios (ORs) for AVC across CVH categories; and restricted cubic spline models were applied to assess the dose–response relationship.ResultsA total of 2; 894 AVC cases were identified. Compared with low CVH; moderate CVH was associated with lower odds of AVC (OR = 0.53; 95% CI: 0.47–0.61); and high CVH was associated with even lower odds of AVC (OR = 0.25; 95% CI: 0.15–0.40). A linear inverse association between TWC-LE8 score and AVC was observed (P for trend < 0.001). Age-stratified analyses showed significant heterogeneity. Among participants aged ≥55 years; high CVH was associated with 74% lower odds of AVC (OR = 0.26; 95% CI: 0.15–0.45); whereas no significant association was observed among those aged <55 years.ConclusionHigher cumulative LE8 scores were strongly associated with lower odds of AVC; particularly among older adults. These findings support an inverse association between long-term cardiovascular health and AVC.
Keywords:
aortic valve calcification
cardiovascular health
Kailuan study
LE8
time-weighted cumulative Life's Essential 8 scores
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