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The ATF4/PSAT1/JNK Signaling Axis Suppresses Ferroptosis to Drive Venetoclax Resistance in AML

delete2026-04-25
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PRE
AI
X
Xunxun Zhu
W
WenHui Huang
M
Mingyan Zhang
Y
YanLing Tao
H
Hao Zhang *
DOI：10.1016/j.yexcr.2026.115045delete
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Abstract

Abstract

En 中文
• Single-Cell Transcriptomics Identifies Chemoresistant AML Subpopulations Enriched in Ferroptosis-Associated Genes. • PSAT1 is Upregulated in VEN-Resistant AML and Predicts Poor Clinical Outcome. • PSAT1 Contributes to VEN Resistance in AML Cells. • PSAT1 Suppresses Ferroptosis to Confer VEN Resistance.
Keywords:
PSAT1
Ferroptosis
Venetoclax resistance
AML
ATF4/PSAT1/JNK signaling axis

Journal

Experimental Cell Research cover
Experimental Cell Research
IF:
3.5
Papers:
1.1W
Citations:
2.0W

Organization

J
jining medical university
Scholars:
758
Papers: 215
Citations: 0
S
Shandong Province
Scholars:
64
Papers: 16
Citations: 0
T
tengzhou central people's hospital
Scholars:
3
Papers: 3
Citations: 0
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