1
Return

The case for N-acetylcysteine in dengue associated liver injury: time for definitive evidence

delete2026-07-07
delete0
delete
OA
AI
A
Angela McBride *
N
Nguyen Lam Vuong
S
Sudeep Adhikari
S
Su Myat Han
P
Po Ying Chia
H
Huynh Trung Trieu
P
Phung Khanh Lam
H
Ho Quang Chanh
G
Giri Rajahram
T
Tsin Wen Yeo
E
Evelyne Kestelyn
J
James Watson
T
Truong Ngoc Trung
S
Sophie Yacoub
DOI：10.1093/ofid/ofag421delete
deleteOriginal
deleteOriginal request for help
deleteShare
deleteSave
Abstract

Abstract

En 中文
Dengue-associated liver injury is common, prognostically significant, and associated with high mortality at severe thresholds. Oxidative stress is a key, potentially modifiable mechanism. N-acetylcysteine has strong biological plausibility and supportive preclinical data, but clinical evidence remains limited, underscoring the need for well-designed randomised trials to inform practice and policy.

Journal

Open Forum Infectious Diseases cover
Open Forum Infectious Diseases
IF:
3.8
Papers:
6.3K
Citations:
1.4W

Organization

O
oxford university
Scholars:
278
Papers: 145
Citations: 0
Hospital for Tropical Diseases cover
Hospital for Tropical Diseases
Scholars:
137
Papers: 101
Citations: 149
U
university of oxford
Scholars:
9.6W
Papers: 8.5W
Citations: 137
Queen Elizabeth II Hospital cover
Queen Elizabeth II Hospital
Scholars:
2
Papers: 2
Citations: 113
National Centre for Infectious Diseases cover
National Centre for Infectious Diseases
Scholars:
107
Papers: 34
Citations: 710
N
nagasaki university
Scholars:
1.6K
Papers: 518
Citations: 1
N
National University of Singapore
Scholars:
7.4W
Papers: 6.4W
Citations: 11.4W
Cited Papers

Cited Papers

Citing Papers

Citing Papers