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The CLEC-2–podoplanin axis inhibits dendritic cells migration and prolongs allograft survival in mice
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DOI：10.1016/j.molimm.2026.05.002.png)
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Abstract
En 中文
• Blocking the CLEC-2-PDPN axis prolongs skin allograft survival. • PDPN blockade reduces migratory cDC2 accumulation in lymph nodes. • Impaired cDC2 homing broadly suppresses T cell alloimmunity. • The therapy increases IL-10, fostering a tolerogenic state.
Keywords:
CLEC-2
PDPN
dendritic cell migration
allograft survival
tolerogenic state