The combined impact of HLA and non-HLA mismatch between donors and recipients on kidney transplant survival: a genomic analysis in a prospective cohort

Michael Kammer

doi:10.1016/j.ebiom.2026.106420

The combined impact of HLA and non-HLA mismatch between donors and recipients on kidney transplant survival: a genomic analysis in a prospective cohort

2026-08-05

0

OA

AI

M

Michael Kammer

A

Andreas Heinzel

S

Stephen Shoebridge

R

Roman Reindl‐Schwaighofer

K

Karin Hu

H

Hao Shan Chen

A

Alexander Kainz

I

Ismail Daoudi

A

Ana F. David

G

Gottfried Fischer

B

Brendan Keating

M

Matthias Niemann

R

Rainer Oberbauer *

DOI：10.1016/j.ebiom.2026.106420

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Abstract

En 中文

Kidney transplantation outcomes are strongly influenced by immunological compatibility between donor and recipient. While genetic mismatches in the human leukocyte antigen (HLA) region have long been recognised as key determinants of graft survival, increasing evidence, including our own previous work, suggests that non-HLA alloimmunity also plays a critical role.

Keywords:

Kidney transplantation

Histocompatibility

HLA matching

Graft failure risk

The combined impact of HLA and non-HLA mismatch between donors and recipients on kidney transplant survival: a genomic analysis in a prospective cohort

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