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The effects of dietary oxyberberine supplementation on the growth performance, carcass traits, blood biochemical parameters and intestinal health in broilers
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DOI：10.1016/j.psj.2026.107249.png)
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Abstract
En 中文
Oxyberberine (OBB), a novel intestinal metabolite of berberine (BBR), has demonstrated anti-tumor, anti-inflammatory and antioxidant activities superior to those of BBR. Nevertheless, current studies on OBB have focused primarily on rodents, and its potential as a livestock feed additive for nutritional regulation remains largely unexplored. The present study aimed to elucidate the effect of dietary OBB on growth performance, biochemical parameters and intestinal health of broilers. A total of 300 1-d female broilers (Shengze 901+) were randomized into five treatment groups (6 pens/treatment and 10 birds/pen): basal diet group as control (Control), basal diet + 50 mg/kg BBR (BBR 50), basal diet + 25 mg/kg OBB (OBB 25), basal diet + 50 mg/kg OBB (OBB 50), basal diet + 75 mg/kg OBB (OBB 75). The feeding trial lasted for 6 weeks, dividing into an early stage (1-21 d) and a late stage (21-42 d). These findings demonstrated that supplementing with 25 mg/kg OBB dramatically improved the growth performance of broilers during the later growth phase (P < 0.05), and also apparently increased semi-eviscerated, eviscerated and breast muscle weights (P < 0.05). OBB supplementation markedly increased the activities of SOD, CAT, T-AOC and GSH-Px (P < 0.05), while also significantly decreasing serum DAO and enhancing immune function by boosting IgA, IgM, and IgG concentrations (P < 0.05). OBB supplementation markedly (P < 0.05) lowered serum UN, TC, and TG levels, as well as noticeably upregulated the expressions of tight junction proteins and augmented the number of goblet cells (P < 0.05). 16S rRNA sequencing revealed that significant enrichment of Prevotellaceae, Desulfovibrio and Bacillales in the OBB 25 group. Taken together, supplementation with OBB, especially 25 mg/kg, could improve growth performance and slaughter performance, which may be related to improving antioxidation capacity, immune function and intestinal barrier function.
Keywords:
Oxyberberine
Immunity
Antioxidant capacity
Gut microbiota
Broiler
ADFI
Average daily feed intake
ADG
Average daily gain
ALT
Alanine aminotransferase
ALB
Albumin
AST
Aspartate aminotransferase
ALP
Alkaline phosphatase
UN
Urea nitrogen
BW
Body weight
BBR
Berberine
CAT
Catalase
ELISA
Enzyme-linked immunosorbent assay
F/G
Feed to weight gain ratio
GSH-Px
Glutathione peroxidase
H&E
Hematoxylin and eosin stain
IgA
Immunoglobulin A
IgG
Immunoglobulin G
IgM
Immunoglobulin M
IFN-γ
Interferon-γ
IL-10
Interleukin-10
IL-1β
Interleukin-1β
MDA
Malondialdehyde
NRC
National research council
PBS
Phosphate-buffered saline
PCA
Principal component analysis
PFA
Paraformaldehyde
PLS-DA
Partial least squares discriminant analysis
SEM
Standard error of means
SOD
Superoxide dismutase
H&E
Hematoxylin and eosin
T-AOC
Total antioxidant capacity
TCM
Traditional Chinese Medicine
TC
Total cholesterol
TG
Triglyceride
OBB
Oxyberberine
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