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The Electrophilic Thiocyanation/Cyclization Reaction of Allenic Acids: One-Step Preparation of Thiocyanated 2(5H)-furanones
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DOI：10.1002/ajoc.70466.png)
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Abstract
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Using electrophilic thiocyanating reagents as the thiocyanogen source, a series of 4-thiocyanato-2(5H)-furanones was rapidly synthesized in one step via electrophilic thiocyanation cyclization under Lewis acid catalysis, with the highest yield reaching 94%. This reaction proceeds under mild conditions without oxidants or metal reagents and is compatible with various substituents. It not only provides a new method for the preparation of 2(5H)-furanones but also offers a novel route for the synthesis of sulfur-containing 2(5H)-furanone derivatives.
Keywords:
2(5H)-furanone
cyclization
electrophilic
thiocyanates
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