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The emerging role of astrocytes in spatial cognition; action and Alzheimer’s disease
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DOI：10.3389/fncel.2026.1811370.png)
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Abstract
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Astrocytes sense synaptic activity; neuromodulation; and metabolic signals; and respond by modulating neurotransmission; excitability; and plasticity in neural networks. Increasing evidence demonstrates that these processes contribute to information processing and encoding across brain areas; thereby influencing perception; memory; cognition; and goal-directed behaviours. Notably; impairments in these functions represent some of the earliest hallmarks of ageing and neurodegenerative disorders such as Alzheimer’s disease. Here we review molecular; cellular; and computational insights into astrocyte-neuron interactions; framing their importance at the system and behavioural level; then; we discuss the role of these interactions in spatial cognition; goal-directed behaviour; and their impairment in Alzheimer’s disease; and review the mouse models used to investigate spatial deficits and associated astrocyte activity. Finally; we highlight major open questions in the field; outline future research directions; and discuss emerging strategies to address astrocyte role in cognitive function in health and disease.
Keywords:
astrocytes
Alzheimer’s disease
spatial memory
goal-oriented behaviour
neuro-glia interaction
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