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The epigenetic control of inflammaging in skeletal muscle and adipose tissue
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DOI：10.1016/j.mad.2026.112205.png)
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Abstract
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• Progressive mitochondrial dysfunction in skeletal muscle and white adipose tissue sustain chronic inflammation in ageing. • The accumulation of lipids and impaired mitochondrial quality control reinforces a pro-inflammatory phenotype in ageing. • Caloric restriction and exercise training activate AMPK–SIRT1–PGC-1α pathways, suppressing inflammation through epigenetic in ageing.
Keywords:
Inflammaging
Exercise
Nutrition
Epigenetics
Ageing
Insulin Resistance
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