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The functional roles of macrophage migration inhibitory factor in the tumor microenvironment
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DOI：10.1016/j.cytogfr.2026.07.002.png)
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Abstract
En 中文
• Structure, sources, localization and receptors underlie MIF functional heterogeneity. • The tumor microenvironment shapes the functional diversity of MIF in cancer. • MIF remodels immune, metabolic, and stromal niches to influence tumor progression. • Stratifying MIF by molecular and TME may guide biomarker and therapeutic translation.
Keywords:
Macrophage migration inhibitory factor
Functional heterogeneity
Tumor microenvironment
Cancer progression
Therapeutic target