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The identification of SiMyD88 confirms the presence of a functional TLR-MyD88-IRAK signaling axis in the sea urchin Strongylocentrotus intermedius
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DOI：10.1016/j.fsi.2026.111118.png)
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Abstract
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• SiMyD88 was identified and characterized in the sea urchin Strongylocentrotus intermedius. • SiMyD88 expression was induced by LPS and poly(I:C) challenge. • SiMyD88 interacted with TLR proteins and was capable of self-association. • SiMyD88 interacted directly with IRAK. • SiMyD88 dose-dependently activated the IL-6, AP-1, and NF-κB reporter genes.
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