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The immunology of systemic lupus erythematosus
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DOI：10.1038/s41590-024-01898-7.png)
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Abstract
En 中文
Understanding the pathogenesis and clinical manifestations of systemic lupus erythematosus (SLE) has been a great challenge. Reductionist approaches to understand the nature of the disease have identified many pathogenetic contributors that parallel clinical heterogeneity. This Review outlines the immunological control of SLE and looks to experimental tools and approaches that are improving our understanding of the complex contribution of interacting genetics, environment, sex and immunoregulatory factors and their interface with processes inherent to tissue parenchymal cells. Efforts to advance precision medicine in the care of patients with SLE along with treatment strategies to correct the immune system hold hope and are also examined. In this Review, the author outlines the complex immunology of systemic lupus erythematosus and how to treat it.
Keywords:
REDUCES DISEASE-ACTIVITY
T-CELL-ACTIVATION
GMP-AMP SYNTHASE
I INTERFERON
MAMMALIAN TARGET
N-ACETYLCYSTEINE
AUTOIMMUNITY
EXPRESSION
RAPAMYCIN
DNA