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The impact of long-term feeding with curcuminoids phospholipids enriched diet on disease progression of fALS
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DOI：10.1016/j.neuint.2026.106183.png)
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Abstract
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• ALS is a fatal neurodegenerative disease characterised by the progressive loss of motor functions. • SOD1 mouse model for fALS shows sexual dimorphism in regard to disease onset and progression. • Long-term feeding with curcuminoids phospholipids enriched diet led to reduced anxiety like behavior in female SOD1 mice. • Curcumin supplementation had a no significant effect on disease onset and progression in SOD1 mice model for fALS.
Keywords:
ALS
Excitability
Motoneuron disease
SOD1
Locomotion
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