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The Interplay Between Explainability and Differential Privacy in Federated Healthcare

delete2026-01-01
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PRE
AI
M
Marc Molina Van De Bosch *
A
Andrea Protani
R
Riccardo Taiello
L
Lorenzo Giusti
M
M. Costa
I
Ioannis Stathopoulos
E
Efstathios Efstathopoulos
D
Diogo Reis Santos
M
Miguel Á. González Ballester
L
Luigi Serio
DOI:10.1007/978-3-032-05663-4_13delete
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Abstract

Abstract

En 中文
Federated Learning (FL) enables the training of deep learning models on siloed medical data. Its real-world application is often challenged by statistical heterogeneity, privacy requirements, and the need for model transparency. This paper addresses these challenges by investigating the interplay between FL, Differential Privacy (DP), and model explainability for 3D medical image segmentation. To simulate a realistic environment, we establish a cross-silo federation of four clients, comprising data from the BraTS dataset and a distinct heterogeneous dataset from a real hospital in Europe. Our analysis characterizes and quantifies an interaction, namely the phHeterogeneity Amplifier effect, providing a metric to measure the disproportionate degradation of explanation fidelity on heterogeneous clients under DP. To address this challenge, we propose Boundary-Interior Disentangled CAM (BID-CAM), a hybrid explanation method designed for DP-awareness. Our evaluation shows that BID-CAM maintains explanation fidelity under privacy constraints with respect to standard methods, demonstrating a more robust approach to model transparency in private, federated settings applied to medical imaging.
Keywords:
Federated Learning
Medical Image Segmentation
Explainable AI
Differential Privacy
Data Heterogeneity
Grad-CAM

Journal

B
BRIDGING REGULATORY SCIENCE AND MEDICAL IMAGING EVALUATION; AND DISTRIBUTED, COLLABORATIVE, AND FEDERATED LEARNING, MICCAI 2025
IF:
0
Papers:
15
Citations:
0

Organization

P
pompeu fabra university
Scholars:
423
Papers: 275
Citations: 4
E
european organization for nuclear research (cern)
Scholars:
420
Papers: 87
Citations: 0
E
ecole polytechnique federale de lausanne
Scholars:
796
Papers: 389
Citations: 0
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