The Interplay Between Loneliness, Cortisol, and NK Cell Function: The Role of Cortisol in NK Cell Dysfunction

Abhinav Saurabh

doi:10.1016/j.psyneuen.2026.107870

The Interplay Between Loneliness, Cortisol, and NK Cell Function: The Role of Cortisol in NK Cell Dysfunction

2026-04-27

0

PRE

AI

A

Abhinav Saurabh

Y

Yvonne Baumer

L

Laurel G. Mendelsohn

E

Elizabeth M. Aquino Peterson

D

Dana Sandler

S

Shirley J. Lopez De Leon

A

Ayushi Dave

A

Andrew S. Baez

L

Lola R. Ortiz-Whittingham

M

Mario A. Pita

M

Manuel A. Cintron

H

Hannatu Tarfa

S

Sandy Reynolds

S

Shelby R. Hicks

S

Sonal Sharda

J

J. Eleanor Seo

M

Maria Lopez-Ocasio

P

Pradeep K. Dagur

S

Skyler A. Kuhn

N

Neelam Redekar

DOI：10.1016/j.psyneuen.2026.107870

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Abstract

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• Cortisol, as a marker of psychosocial stress, associates with altered NK cell distribution. • The interplay between cortisol and NK cells is moderated by loneliness. • Cortisol impairs NK cell degranulation and cytokine production. • Cortisol may mediate an increase in PD-1 surface expression on NK cells. • Cortisol-mediated PD-1 increase and NK function loss are FABP4 dependent.

Keywords:

Cortisol

NK cells

Loneliness

PD-1

FABP4

The Interplay Between Loneliness, Cortisol, and NK Cell Function: The Role of Cortisol in NK Cell Dysfunction

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