.png){kind=icon}
.png){kind=icon}
Return
The Lung-Brain Axis in Cognitive Impairment and Dementia: Mechanisms and Therapeutic Prospects
.png){kind=icon}
PRE
AI
D
Y
S
W
Y
DOI：10.14336/AD.2026.0095.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
The lung-brain axis has been recognized as a critical interface linking lung health to cognitive disorders, including cognitive impairment, Alzheimer's disease, and dementia. Epidemiological and clinical evidence shows a close association between compromised lung health-including chronic obstructive pulmonary disease (COPD), asthma, obstructive sleep apnea (OSA), and pulmonary infections-and cognitive impairment and dementia. Potential mechanisms include established factors (systemic inflammation and immune crosstalk, hypoxic injury, and air-pollutant-induced neurotoxicity) and exploratory mechanisms (lung microbiome dysregulation). Notably, lung-centric strategies targeting the lung-brain axis involve repurposing pulmonary medications, intervening in shared mechanisms, and employing non-pharmacological strategies. Furthermore, realizing this promise will require future randomized controlled trials (RCTs) to develop comprehensive management strategies and alleviate the global burden of cognitive impairment and dementia.
Keywords:
Lung-brain axis
Cognitive impairment
Dementia
Alzheimer's disease
Mechanisms
Therapeutic strategies
Journal
A
IF:
6.9
Papers:
1.4K
Citations:
7.6K
Organization
Cited Papers