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The m6A epitranscriptome: transcriptome plasticity in brain development and function
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DOI：10.1038/s41583-019-0244-z.png)
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Abstract
En 中文
The field of epitranscriptomics examines the recently deciphered form of gene expression regulation that is mediated by type- and site-specific RNA modifications. Similarly to the role played by epigenetic mechanisms -which operate via DNA and histone modifications-epitranscriptomic modifications are involved in the control of the delicate gene expression patterns that are needed for the development and activity of the nervous system and are essential for basic and higher brain functions. Here we describe the mechanisms that are involved in the writing, erasing and reading of N-6-methyladenosine, the most prevalent internal mRNA modification, and the emerging roles played by N-6-methyladenosine in the nervous system.
Keywords:
MESSENGER-RNA METHYLATION
LOCAL TRANSLATION
FAT MASS
BINDING PROTEINS
GENE-EXPRESSION
NUCLEAR-RNA
N-6-METHYLADENOSINE
REVEALS
PSEUDOURIDYLATION
NEUROGENESIS
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