The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and development

2026-04-21

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Shalini Chakraborty

Steven Florez

Jack Govaerts

Abigail Hawke

Todd A. Schoborg *

DOI：10.1016/j.ydbio.2026.04.014

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Abstract

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• Asp expression in symmetrically dividing neuroepithelial cells (NECs) can rescue optic lobe brain size and morphology defects in asp mutants. • Asp expression in asymmetrically dividing neuroblasts cannot rescue optic lobe brain size or morphology defects in asp mutants. • Expression of Asp in NECs is only required during the second neurogenesis phase to promote proper adult brain development. • The human ortholog of Asp (ASPM) can significantly rescue fly optic lobe brain growth defects, suggesting conservation of function between Drosophila and humans. • Asp’s nuclear localization is not required for brain growth and development.

Keywords:

Asp

neuroepithelial cells

asymmetric division

brain development

ASPM

The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and development

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