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The multifaceted mitochondrial OXA insertase
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DOI：10.1016/j.tcb.2023.02.001.png)
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Abstract
En 中文
Most mitochondrial proteins are synthesized in the cytosol and transported into mi-tochondria by protein translocases. Yet, mitochondria contain their own genome and gene expression system, which generates proteins that are inserted in the inner membrane by the oxidase assembly (OXA) insertase. OXA contributes to targeting proteins from both genetic origins. Recent data provides insights into how OXA cooperates with the mitochondrial ribosome during synthesis of mitochondrial-encoded proteins. A picture of OXA emerges in which it coordinates insertion of OXPHOS core subunits and their assembly into protein complexes but also participates in the biogenesis of select imported proteins. These functions po-sition the OXA as a multifunctional protein insertase that facilitates protein transport, assembly, and stability at the inner membrane.
Keywords:
CYTOCHROME-C-OXIDASE
PROTEIN EXPORT MACHINERY
INNER-MEMBRANE
F1FO-ATP SYNTHASE
QUALITY-CONTROL
NUCLEAR GENE
YIDC
TRANSLOCATION
BIOGENESIS
INTERACTS
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