The multifaceted role of acetamide derivative of chalcone: Anti-inflammatory action and impact on osteoclastogenesis, insights on NF-κB and MAPK pathway

Sobia Anjum

doi:10.1016/j.cyto.2026.157185

The multifaceted role of acetamide derivative of chalcone: Anti-inflammatory action and impact on osteoclastogenesis, insights on NF-κB and MAPK pathway

2026-07-03

0

PRE

AI

S

Sobia Anjum

T

Tazeem Akram

U

Unnatti Sharma

O

Omesh Manhas

J

Jasha Momo H. Anal

G

Gurleen Kour *

Z

Zabeer Ahmed *

DOI：10.1016/j.cyto.2026.157185

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• Chalcone derivatives 7a inhibited nitric oxide and pro-inflammatory cytokine production in LPS stimulated RAW 264.7 cells. • 7a suppressed osteoclastogenic activity in RANKL-induced osteoclast cells. • 7a downregulated the activation of NF-κB and MAPK signaling pathways involved in inflammation and osteoclastogenesis. • In-vivo, 7a reduced LPS induced systemic inflammation, carrageenan-induced paw edema and serum levels of CRP and LDH.

The multifaceted role of acetamide derivative of chalcone: Anti-inflammatory action and impact on osteoclastogenesis, insights on NF-κB and MAPK pathway

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