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The multifaceted role of B lymphocytes in type 1 diabetes
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DOI：10.1016/j.smim.2026.102034.png)
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Abstract
En 中文
Lymphocytes B cells (B cells) play a determinant role in the pathogenesis of type 1 diabetes (T1D); indeed, B cells antigen-presentation capabilities are largely described as a main contributing pathogenic factor. Recent evidences highlighted the role of islet antigen-reactive B cells as a perpetuated contributor to autoantibodies seroconversion and the progression to the late stages of the disease. A loss of B cells anergy towards islet-specific antigens, can be recognized in T1D. Aside from their well characterized role during the pathogenesis and early onset of T1D, a fundamental regulatory role of a subset of B cells, namely regulatory B cells, has proven its relevance in the time course of the disease. Since targeting B cells showed little or no additional benefits; instead, harnessing strategies to expand B regulatory cells could represent an attractive therapeutic path to tackle inflammation and curb diabetes.
Keywords:
B cells
Type 1 diabetes
NOD mice
Autoreactive B cells
Cytokines
Antigen presentation
Regulatory B cells
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