.png){kind=icon}
.png){kind=icon}
Return
The nonpeptide angiotensin-(1–7) mimic AVE0991 attenuates neuroendocrine and behavioral responses to chronic unpredictable stress
.png){kind=icon}
OA
AI
M
L
S
L
L
F
M
M
R
M
L
DOI：10.1007/s00213-026-07126-4.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Chronic stress, frequently associated with dysfunction of the hypothalamic–pituitary–adrenal (HPA) axis and reduced neuroplasticity, is a major risk factor for psychiatric disorders such as anxiety and depression. The present study aimed to validate a 21-day chronic unpredictable stress (CUS) model and to investigate the effects of the Mas receptor agonist AVE0991 on stress-induced behavioral and molecular alterations. Male C57BL/6J mice were exposed to a 21-day CUS protocol. Animals were randomly assigned to four groups: control + saline, CUS + saline, control + AVE0991, and CUS + AVE0991 (3 mg/kg, i.p.). AVE was administered daily during the last two weeks of the stress protocol. Behavioral tests were performed to evaluate anxiety- and depressive-like behaviors, and plasma corticosterone, blood glucose levels, and brain-derived neurotrophic factor (BDNF) levels in the prefrontal cortex, hippocampus, and hypothalamus were measured. CUS exposure significantly increased plasma corticosterone and glucose levels and induced anxiety- and depressive-like behaviors. Stressed animals also showed reduced BDNF levels in the prefrontal cortex, hippocampus, and hypothalamus. Treatment with AVE0991 attenuated the increase in corticosterone and prevented stress-induced hyperglycemia. Moreover, AVE0991 reduced depressive-like behavior, increased latency to immobility, and improved anxiety-related parameters in the elevated plus maze and open field tests without affecting locomotor activity. AVE0991 also prevented the reduction of BDNF levels in stress-exposed animals. These findings validate the CUS model and demonstrate that activation of the Mas receptor by AVE0991 exerts anxiolytic, antidepressant, and neuroprotective effects, supporting its potential as a therapeutic strategy for stress-related neuropsychiatric disorders.
Keywords:
Chronic unpredictable stress
Anxiety
Depression
AVE0991
BDNF
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
3.3
Papers:
1.1W
Citations:
2.0W
Organization
Cited Papers