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The Orally Available Ghrelin Receptor-Agonist AC01 Improves Systolic Function in HFrEF Mice and Nonhuman Primates
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DOI：10.1016/j.jacbts.2026.101635.png)
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Abstract
En 中文
• The central defect in HFrEF is impaired contractility. • AC01 improved cardiac output, stroke volume, and ejection fraction in HFrEF mice. • AC01 improved systolic function in a pre-load and after-load-independent manner. • Oral AC01 improved cardiac function and autonomic balance in nonhuman primates. • AC01 showed rapid and sustained inotropic effects across species.
Keywords:
AC01
contractility
ghrelin receptor agonist
hemodynamics
HFrEF
inotrope
CO
cardiac output
dP/dTmax
maximum rate of pressure development
dP/dTmin
minimum rate of pressure development
EDPVR
end-diastolic pressure volume relationship
EF
ejection fraction
ESPVR
end-systolic pressure-volume relationship
GHSR1a
growth hormone secretagogue receptor 1a
HFAM
high-frequency autonomic modulation
HFrEF
heart failure with reduced ejection fraction
HR
heart rate
LV
left ventricle
PRSW
preload recruitable stroke work
PV
pressure-volume
SV
stroke volume
TAC
transverse aortic constriction
tau
relaxation time constant
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