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The Physical Senotype in Cellular Senescence: Mechanical and Physical Strategies for Senotherapy
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DOI：10.1016/j.arr.2026.103283.png)
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Abstract
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• Proposes that senescence may be sustained by impaired mechanotransduction and reduced mechanical plasticity, in addition to biochemical damage and SASP signaling. • Defines the “Physical Senotype” as a conceptual framework encompassing cytoskeletal, nuclear, trafficking, and cell–ECM changes associated with senescent states. • Organizes emerging physical senotherapies into direct senescent-cell elimination, mechanically primed immune clearance, and mechanical rejuvenation or reprogramming. • Highlights mechanotransduction and the mechanical microenvironment as emerging, context-dependent targets for senescence-associated tissue dysfunction.
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