The postsubiculum as a head-direction cortex

Adrian J. Duszkiewicz

doi:10.1016/j.tins.2025.09.004

The postsubiculum as a head-direction cortex

2025-10-09

0

PRE

AI

A

Adrian J. Duszkiewicz *

DOI：10.1016/j.tins.2025.09.004

Original

Original request for help

Save

Abstract

En 中文

The rodent head-direction system encodes a 1D variable – the orientation of the head in the horizontal plane – that uses vestibular signals stabilized by multimodal sensory inputs. This head-direction signal is transmitted to the cortex through a thalamocortical loop between the anterodorsal thalamus and the postsubiculum. This circuit resembles primary cortical systems: it features a strong thalamic driver input, broad cortical tuning to head direction, and a transformation of neural tuning along the thalamocortical pathway. Beyond broadcasting the head-direction signal to higher-order cortical areas, this thalamocortical system may also support memory-related information processing during both wakefulness and sleep.

The postsubiculum as a head-direction cortex

Abstract

Journal

Organization