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The pro-inflammatory cytokines IFN-α and TNF-α inhibit organoid-derived extravillous trophoblast invasion
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DOI：10.1016/j.isci.2026.116431.png)
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Abstract
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• IFN-α/TNF-α reduce extravillous trophoblast invasion despite normal differentiation • The cytokines impair trophoblast invasion in organoid and decidua co-culture models • IFN-α/TNF-α alter the expression of invasion-related pathways and key pro-invasive genes • Reduced trophoblast invasion may underlie adverse outcomes in lupus pregnancies
Keywords:
molecular biology
immunology
developmental biology
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