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The redox-active CXXC motif of BCAT1 regulates extracellular vesicle biogenesis in U937 macrophages

delete2026-05-09
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PRE
AI
J
James Hillier
M
Mathieu Brunet
R
Rebecca Terry
J
Joanne Whittaker
G
Gemma Allcot
S
Sophie C. Cox
P
Patricia Pérez Esteban
S
Steven Coles
I
Ivan Wall
DOI：10.1016/j.yexcr.2026.115049delete
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Abstract

Abstract

En 中文
• BCAT1 contains a redox-active CXXC motif that lowers intracellular ROS in U937 cells • WT BCAT1 expression is associated with reduced CD14/CD68, consistent with M2-like polarization • WT BCAT1 significantly increases EV release compared to CXXC-mutant and vector controls • Enhanced EV production occurs under both normal serum and serum-starved conditions • EV populations are predominantly CD63+, with serum starvation amplifying CD63+ EV release • BCAT1 and its CXXC motif play a previously unrecognized role in macrophage EV biogenesis
Keywords:
BCAT1
CXXC motif
extracellular vesicles
U937 cells
macrophage polarization

Journal

Experimental Cell Research cover
Experimental Cell Research
IF:
3.5
Papers:
1.1W
Citations:
2.0W

Organization

U
University of Worcester
Scholars:
502
Papers: 509
Citations: 723
U
university of birmingham
Scholars:
4.2K
Papers: 2.0K
Citations: 0
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