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The Regulated Cell Death Nexus: From Molecular Mechanisms to NINJ1-Mediated Membrane Rupture
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DOI：10.1016/j.pbiomolbio.2026.05.002.png)
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Abstract
En 中文
• A comprehensive overview of key regulated cell death (RCD) pathways is presented, detailing the molecular mechanisms of apoptosis, pyroptosis, ferroptosis, and necroptosis. • Intricate crosstalk and functional cooperativity among distinct RCD modalities are emphasized, culminating in the emerging concept of PANoptosis as a unified cell death machinery. • NINJ1 is highlighted as a universal executioner of plasma membrane rupture, representing a novel and promising therapeutic target for controlling the inflammatory outcome of lytic cell death.
Keywords:
regulated cell death
apoptosis
pyroptosis
ferroptosis
necroptosis
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