.png){kind=icon}
.png){kind=icon}
Return
The relationship among cognitive reserve and symptoms; cognition; and functioning in schizophrenia: A case–control study and meta-analysis
.png){kind=icon}
OA
AI
L
C
H
Y
C
C
S
X
DOI：10.1192/j.eurpsy.2026.12216.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
BackgroundCognitive reserve (CR) is considered a positive factor in the onset; progression; and prognosis of diseases. It may also help explain the clinical heterogeneity observed in schizophrenia (SZ).MethodsThis cross-sectional study included 70 patients with SZ and 64 healthy controls. Participants were assessed on CR; symptoms; cognition; and functional outcomes. Following PRISMA guidelines; we also searched PubMed; Scopus; Web of Science; Embase; the Cochrane Library; and PsycINFO for studies published up to September 25; 2025. Study quality was evaluated using the Newcastle-Ottawa Scale (NOS).ResultsPatients with higher CR showed less severe negative and general psychopathological symptoms; along with better functional outcomes. Meta-analysis confirmed this relationship and further revealed positive correlations between CR and multiple cognitive domains; including speed of processing; working memory; verbal learning; visual learning; and reasoning and problem solving.ConclusionsThis study demonstrates a positive association between CR and symptoms severity; cognitive performance; and functional outcomes in SZ.
Keywords:
cognitive reserve
functional outcomes
negative symptoms
schizophrenia
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
6.7
Papers:
2.1W
Citations:
8.1K
Organization
Cited Papers