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The response of the melanized yeast Exophiala dermatitidis to gamma radiation exposure
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DOI：10.1111/1462-2920.14936.png)
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Abstract
En 中文
The melanized yeast Exophiala dermatitidis is resistant to many environmental stresses and is used as a model for understanding the diverse roles of melanin in fungi. Here, we describe the extent of resistance of E. dermatitidis to acute gamma-radiation exposure and the major mechanisms it uses to recover from this stress. We find that melanin does not protect E. dermatitidis from gamma-radiation. Instead, environmental factors such as nutrient availability, culture age and culture density are much greater determinants of cell survival after exposure. We also observe a dramatic transcriptomic response to gamma-radiation that mobilizes pathways involved in morphological development, protein degradation and DNA repair, and is unaffected by the presence of melanin. Together, these results suggest that the ability of E. dermatitidis to survive gamma-radiation exposure is determined by the prior and the current metabolic state of the cells as well as DNA repair mechanisms, and that small changes in these conditions can lead to large effects in radiation resistance, which should be taken into account when understanding how diverse fungi recover from this unique stress.
Keywords:
LIQUID-HOLDING RECOVERY
DOUBLE-STRAND BREAKS
DNA-DAMAGE RESPONSE
IONIZING-RADIATION
SACCHAROMYCES-CEREVISIAE
WILD-TYPE
MAMMALIAN-CELLS
LECANII-CORNI
RESISTANCE
REPAIR
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