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The RNA-binding protein ALYREF promotes mitochondrial dysfunction and ferroptosis in CD4+ helper T cells in chronic obstructive pulmonary disease and non-small cell lung cancer by enhancing ZWINT mRNA stability
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DOI：10.1016/j.cellimm.2026.105098.png)
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Abstract
En 中文
• ZWINT expression is significantly upregulated in the COPD-NSCLC model and drives CD4+ T cell exhaustion and ferroptosis in vivo. • ZWINT directly induces mitochondrial dysfunction and ferroptosis in CD4+ T cells in vitro. • The tumorigenic effect of ALYREF depends on its regulation of the downstream target ZWINT.
Keywords:
ZWINT
CD4+ T cells
ferroptosis
ALYREF
mitochondrial dysfunction
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