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The road to modularity
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DOI：10.1038/nrg2267.png)
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Abstract
En 中文
A network of interactions is called modular if it is subdivided into relatively autonomous, internally highly connected components. Modularity has emerged as a rallying point for research in developmental and evolutionary biology (and specifically evo-devo), as well as in molecular systems biology. Here we review the evidence for modularity and models about its origin. Although there is an emerging agreement that organisms have a modular organization, the main open problem is the question of whether modules arise through the action of natural selection or because of biased mutational mechanisms.
Keywords:
QUANTITATIVE TRAIT LOCI
EPISTATIC PLEIOTROPY
GENETIC ARCHITECTURE
REGULATORY MODULES
BODY-SIZE
EVOLUTION
EVOLVABILITY
COVARIATION
INTEGRATION
EXPRESSION
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52
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4.0K
Citations:
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