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The role of apolipoprotein C1 in mediating pyroptosis in Hashimoto’s thyroiditis via TLR10/MyD88/NF-κB pathway
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DOI：10.1016/j.molimm.2026.04.005.png)
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Abstract
En 中文
• Transcriptomics showed that HT linked to inflammation, pyroptosis, lipid metabolism. • APOC1 was the top-ranked DEGs in lipid metabolism regulation. • IL-18/NLRP3 genes were upregulated; IL-18, NLRP3, APOC1 proteins were increased. • APOC1 likely mediated TFC pyroptosis via TLR10/MyD88/NF-κB pathway. • Pyroptosis and lipid metabolism are potential therapeutic targets for HT.
Keywords:
APOC1
pyroptosis
Hashimoto’s thyroiditis
lipid metabolism
TLR10/MyD88/NF-κB pathway