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The role of non-cancer cell infections in oncolytic virus therapy
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DOI：10.1016/j.smim.2025.101998.png)
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Abstract
En 中文
• Oncolytic viruses (OVs) act by eliciting direct oncolysis & antitumour immunity. • OVs can induce tumour regression in the absence of cancer cell infection. • OVs infect non-cancer cells in secondary lymphoid organs, the liver & the tumour. • Non-cancer cell infections affect OV delivery to the tumour & anticancer immunity. • Leveraging non-cancer cell infections allows development of improved OV platforms.
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