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The role of S100B protein as a diagnostic biomarker for brain injury
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DOI：10.1016/j.sbsr.2025.100888.png)
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Abstract
En 中文
• S100B displays concentration-dependent effects on neuronal survival and neurotoxicity. • S100B plays critical roles in nervous system physiology and pathology. • Traumatic brain injury and stroke can be detected via quantification of blood S100B biomarker. • S100B are quantified by a range of sensitive ELISA kits in laboratories. • Biosensor-based PoC exhibit enhanced sensitivity and speed to improve disease diagnostics.
Keywords:
S100B protein
Biomarker
Diagnostics
Traumatic brain injury
Neurological diseases
AD
Alzheimer's disease
AI
Artificial Intelligence
Au NPs
Gold nanoparticles
AuIDEs
Interdigitated gold electrodes
Aβ42
Amyloid-β 1–42
BBB
Blood-brain barrier
CI
Confidential interval
CSF
Cerebrospinal fluid
CT
Computed tomography
DAMP
Damage-associated molecular pattern
DPM–Cu(II)
Dipyrromethene complexed with Cu(II) ions
ELISA
Enzyme-linked Immunosorbent Assay
ER
Endoplasmic reticulum
FDA
Food and Drug Administration
GAD
Generalized anxiety disorder
GFAP
Fibrillary acidic protein
HAuNPs
Hollow gold nanoparticles
ISF
Interstitial fluid
ITO
Indium tin oxide
KD
Dissociation constant
LFA
Lateral flow assay
LFIA
Lateral flow immunoassay
LoD
Limit of Detection
MBT
Mercaptobutanol
mTBI
Mild Traumatic Brain Injury
MUC
Mercaptoundecanoic acid
MVB
Multivesicular body
NFL
National football league
NPV
Negative predictive values
NSE
Neuron-specific enolase
PLFS
Paper lateral flow assay
PoC
Point-of-care
RAGE
Receptor for advanced glycation end products
rGO
Reduced graphene oxide
SERS
Surface-enhanced Raman scattering
SPR
Surface plasmon resonance
TBI
Traumatic brain injury
TJ
Tight junctions
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