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The Role of Small Extracellular Vesicles in Tumor Development and the Prospect of Targeted Therapy
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DOI：10.1111/tra.70023.png)
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Abstract
En 中文
Small extracellular vesicles (sEVs) originate from endosomes formed during cellular endocytosis, have a diameter ranging from 30 to 150 nm and are membrane-bound prior to release, sEVs may also be formed by budding of the plasma membrane to form ectosomes. sEVs transport proteins, RNA, microRNAs (miRNAs), DNA, and other bioactive substances to facilitate information exchange and may function as mediators under physiological conditions. sEVs have various pathological roles, especially when produced by tumor parenchyma and stromal cells for signaling in the tumor-induced microenvironment. The vesicles are considered potential tumor markers and there are broad prospects for developing tumor therapies by inhibiting sEV production, secretion and uptake and eliminating circulating sEVs. sEVs may be modified to deliver chemotherapeutic drugs and this approach has shown promising results for tumor inhibition and improved prognosis. The current study reviews the role of sEVs in tumor development and explores the potential for tumor treatment.
Keywords:
small extracellular vesicle inhibitors
small extracellular vesicles
targeted therapy
tumor immunity
tumor microenvironment
tumor progression
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