The root cause: why do so many drugs fail to translate from bench to bedside?

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2026-06-18

Andre Levchenko *

Mark Corrigan

Bruce Wexler

DOI：10.1080/17460441.2026.2665217

Original request for help

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Abstract

Keywords:

Translational failure

Phase II attrition

organ‑system models

disease heterogeneity

systems pharmacology

IF:

4.9

Papers:

2.2K

Citations:

6.7K

Scholars:

26.2W

Papers: 21.9W

Citations: 28.7W

Scholars:

7.0K

Papers: 3.0K

Citations: 2