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The SIRT1-HMGB1 pathway in hippocampal microglia is involved in chronic heroin-induced cognitive impairment
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DOI：10.1016/j.pbb.2026.174155.png)
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Abstract
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• 30 days, but not 15 days, of chronic heroin treatment could impair the learning and memory of mice in the water maze task • Prolonged heroin administration increased SIRT1- and HMGB1-positive microglia in the hippocampus. • Microglial SIRT1 knockdown worsened hippocampal apoptosis and cognitive impairment after 30 days of heroin treatment. • Microglial SIRT1 knockdown reduced the increase of HMGB1-positive microglia induced by chronic heroin treatment.
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