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The unfolded protein response is a critical mediator in Campylobacter jejuni pathogenesis and host defence
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DOI：10.1016/j.micinf.2025.105582.png)
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Abstract
En 中文
Campylobacter jejuni is the major bacterial cause of foodborne gastroenteritis worldwide. How this pathogen interacts with the host defence machinery of human intestinal epithelial cells (IECs) and is involved in pathogenesis remains elusive. Bacterial pathogens utilise strategies to gain access to the eukaryotic cell machinery that can involve subversion of biological processes in host. Unfolded protein response (UPR) is a highly conserved host cell stress response to the accumulation of misfolded proteins in the endoplasmic reticulum (ER) and is a conserved evolutionary response against invading pathogens. Several bacterial pathogens can induce the UPR for their own survival and thus design a dual scenario where UPR can both protect and facilitate pathogen evasion.
Keywords:
Campylobacter jejuni
Unfolded protein response
ER stress
Inflammation
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