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Therapeutic application of probiotic extracellular vesicles in inflammatory bowel disease
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DOI：10.1016/j.jare.2026.08.016.png)
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Abstract
En 中文
• This review summarizes the biogenesis, composition, and preparation methods of PEVs. • PEVs exert their protective effects for IBD by modulating immune and inflammatory responses, reinforcing the intestinal barrier function, and restoring the gut microbiota. • Significant barriers involving their safety, stability, and scalability need to be addressed to enable their clinical transition. • Target-ligand identification and biodistribution quantification of PEVs in treatment of IBD remain a challenge.
Keywords:
Probiotic extracellular vesicles
Inflammatory bowel disease
Immune response
Intestinal barrier
Gut microbiota
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2.8K
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